Pro-fibrotic Factor Expression

Pro-fibrotic factor expression refers to the increased production of molecules that promote fibrosis, a pathological process characterized by excessive deposition of extracellular matrix components. Key pro-fibrotic factors include TGF-β, CTGF, PAI-1, collagens, fibronectin, and P4HA3. These factors activate signaling pathways that lead to fibroblast proliferation, myofibroblast transdifferentiation, and enhanced ECM protein synthesis, resulting in tissue scarring and organ dysfunction. Targeting pro-fibrotic factor expression, particularly TGF-β signaling, is a major therapeutic strategy for treating fibrosing diseases.

Other names

Upregulation of pro-fibrotic factorsIncreased pro-fibrotic factor production

Inhibition or modulation of TGF-β signaling and downstream pro-fibrotic pathways.