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Target intelligence / Profile preview
Pro-inflammatory Cytokine Signaling (TNF-alpha-induced IL8 Suppression)
- Molecular classification
- Signaling pathway, Cytokine signaling cascade, Inflammatory pathway
01
Overview
Pro-inflammatory cytokine signaling encompasses cellular communication pathways activated by cytokines that promote inflammation. TNF-alpha, a key pro-inflammatory cytokine, induces the expression of inflammatory mediators such as IL-8. While TNF-alpha typically promotes IL-8 production, the pathway can be modulated or suppressed through various mechanisms, including negative feedback loops, crosstalk with other immunomodulatory molecules, and pharmacological interventions targeting upstream or downstream effectors. This pathway plays a critical role in immune responses and inflammation, and is a therapeutic target for autoimmune and inflammatory diseases.
- Other names
- TNF-alpha signaling pathwayIL-8 regulation by TNF-alphaPro-inflammatory cytokine networkTNF-α-induced IL8 Suppression
02
Mechanism of action
Modulation of cytokine expression and signaling pathways involved in inflammation.
03
Biological functions
Immune responseInflammationCell signalingCytokine productionNeutrophil recruitment
04
Disease associations
Inflammatory diseasesAutoimmune diseasesInfectionCancer
05
Safety considerations
Increased risk of infectionInfusion reactionsIncreased risk of certain cancersExacerbation of heart failure
06
Interacting drugs
Infliximab
6 more in the full profile.
07
Biomarkers
TNF-alpha levelsIL-8 levelsNF-kB activationAP-1 activationROS levels
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