Pro-inflammatory Signaling Pathway

The pro-inflammatory signaling pathway is a complex network of molecular and cellular events that promote inflammation. It is triggered by PAMPs and DAMPs, leading to the activation of intracellular signaling cascades such as NF-kB, MAPK, and JAK/STAT pathways. This activation results in the production of pro-inflammatory cytokines like IL-1, IL-6, and TNF-α, which mediate various biological effects, including immune cell recruitment, activation, and apoptosis modulation. Dysregulation of this pathway contributes to chronic inflammatory diseases and cytokine storms.

Other names

Inflammatory pathwayProinflammatory cascade

Multiple mechanisms, including cytokine neutralization, receptor blockade, kinase inhibition, and transcription factor inhibition.