Pro-melanin concentrating hormone like 2 (PMCHL2)

PMCHL2, or Pro-melanin concentrating hormone like 2, is designated as a pseudogene in the human genome. It is predicted to enable type 1 melanin-concentrating hormone receptor binding activity and may be involved in negative regulation of dopaminergic synaptic transmission, but there is no direct evidence for functional protein expression or therapeutic targeting. No established disease relevance or drug interactions are known, and it does not function as a receptor, enzyme, or druggable protein. The functional, drug-targetable melanin-concentrating hormone (MCH) system involves the true PMCH gene (not PMCHL2) and the receptors MCHR1 and MCHR2, which are G protein-coupled receptors relevant in neurobiology and metabolism. PMCHL2 is a pseudogene derived by duplication of the PMCH gene, but does not encode a functional peptide or receptor and thus is not of pharmacological or physiological significance as a drug target. It can be found cataloged in Genecards as a pseudogene with several related gene database identifiers, but no protein-coding or disease target annotation. "Pro-melanin concentrating hormone like 2 (PMCHL2)" is a non-functional pseudogene, not a valid molecular or therapeutic target. For functional targets, refer instead to melanin-concentrating hormone (MCH), MCHR1, or MCHR2.

Other names

GC05U990045GC05P070905GC05P070710GC05P070755GC05P070707GC05P065909