Probable ATP-dependent RNA helicase DDX10 (DDX10)

Probable ATP-dependent RNA helicase DDX10 (DDX10) is an enzyme belonging to the DEAD-box RNA helicase family, characterized by conserved motifs that mediate ATP-dependent RNA unwinding and remodeling[5]. It is crucial for cellular and stem cell homeostasis, ribosome biogenesis, and RNA metabolic processes, including ribosomal RNA (rRNA) processing, particularly the maturation of 18S rRNA and assembly of the small ribosomal subunit[1]. DDX10 localizes predominantly to the nucleolar dense fibrillar and granular components, where it binds and regulates 45S rRNA. Degradation or dysfunction of DDX10, as seen in disease states or via NUP98-DDX10 fusion in cancers, impairs ribosome biogenesis and protein synthesis, leading to cell cycle arrest and apoptosis[1][3]. DDX10 is also involved in liquid-liquid phase separation (LLPS), essential for formation of nucleolar structures and efficient ribosome production[1]. Dysregulation or fusion involving DDX10 contributes to leukemogenesis and is associated with abnormal expression in various solid tumors, modulating cell proliferation and tumorigenic signaling pathways[3].

Other names

DDX10HRH-J8Dbp4DEAD box protein 10DEAD (Asp-Glu-Ala-Asp) box polypeptide 10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)DDX10-NUP98 fusion protein type 2