Probable ATP-dependent RNA helicase DDX23 (DDX23)

Probable ATP-dependent RNA helicase DDX23 (DDX23) is a member of the DEAD box protein family characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif and functions as a putative RNA helicase[1][3][5]. DDX23 is a core component of the U5 small nuclear ribonucleoprotein (snRNP) complex and plays an essential role in nuclear pre-mRNA splicing by facilitating conformational changes in the spliceosome, particularly enabling the transition to the activated B complex[1][7]. Its phosphorylation by SRPK2 is critical for proper spliceosome assembly and for suppressing RNA:DNA hybrids (R-loops), thereby supporting genomic integrity[1]. DDX23 is also implicated in microRNA biogenesis, embryogenesis, spermatogenesis, and general RNA metabolism, with dysfunction linked to neurodevelopmental disorders (e.g., global developmental delay and seizures) and cancer, where it can regulate cancer-associated non-coding RNAs and serve as a candidate biomarker for disease progression[1][3][5][6].

Other names

DEAD-box helicase 23Prp28U5-100KDPRPF28SNRNP100100 kDa U5 snRNP-specific proteinDEAD box protein 23PRP28 homologU5-100kDU5 snRNP-specific 100-kD proteinU5-100Kprp28DEAD (Asp-Glu-Ala-Asp) box polypeptide 23PRP28p homologU5 snRNP 100 kD protein