Probable ATP-dependent RNA helicase DDX27 (DDX27)

Probable ATP-dependent RNA helicase DDX27 (DDX27) is an enzyme of the DEAD-box RNA helicase family, characterized by the conserved Asp-Glu-Ala-Asp motif and ATP-dependent RNA duplex unwinding activity. DDX27 localizes to the nucleolus and is essential for the processing of 5.8S and 28S ribosomal RNAs, interacting specifically with the PeBoW complex for proper 3' end formation of pre-rRNA. It is involved in multiple aspects of RNA metabolism, including translation initiation, splicing, and ribosome assembly, impacting cell cycle progression, growth, and differentiation. DDX27 is overexpressed in various tumors—particularly colorectal and gastric cancers—where it acts as an oncogenic driver by promoting cell proliferation, migration, and invasion through mechanisms including EMT and alternative splicing regulation of metastatic genes (e.g., LPP). High DDX27 expression correlates with poor patient prognosis, increased chemoresistance, and enhanced metastatic potential.

Other names

cPERP-FRHLPHSPC259PP3241dJ686N3.1DRS1DEAD box protein 27Drs1pDEAD (Asp-Glu-Ala-Asp) box polypeptide 27DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27Deficiency of ribosomal subunits protein 1 homologRNA helicase-like protein

Regulating alternative splicing of downstream targets (e.g., LPP in gastric cancer); Promoting epithelial-to-mesenchymal transition (EMT); Inhibiting apoptosis (suppressing caspase activation); Promoting cell proliferation and migration