Probable ATP-dependent RNA helicase DDX28 (DDX28)

Probable ATP-dependent RNA helicase DDX28 is a member of the DEAD-box family of RNA helicases, characterized by the conserved DEAD motif (Asp-Glu-Ala-Asp). It is an enzyme with RNA-dependent ATPase and helicase activities, localized primarily in the mitochondrial matrix, where it plays an essential role in the biogenesis of the mitochondrial large ribosomal subunit (mt-LSU)[3]. DDX28 interacts directly with mitochondrial 16S rRNA, and its silencing leads to impaired mt-LSU assembly, reduced mitochondrial protein synthesis, and deficient assembly of oxidative phosphorylation complexes, resulting in compromised cellular respiration[1][3]. Its activity is indispensable for normal mitochondrial translation and energy metabolism. Mutations or deficiencies in DDX28 are associated with diseases such as Spastic Paraplegia 7 (autosomal recessive) and Perrault syndrome[3]. DDX28 is not currently considered a therapeutic target, and no interacting drugs or mechanisms of action for drug targeting are reported.

Other names

DEAD-box helicase 28DDX28MDDX28FLJ11282Mitochondrial DEAD box protein 28DEAD (Asp-Glu-Ala-Asp) box polypeptide 28DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28