Probable ATP-dependent RNA helicase DDX41 (DDX41)

DDX41 is an ATP-dependent RNA helicase from the DEAD-box family, essential for unwinding RNA and DNA/RNA hybrids in an ATP-dependent fashion. It acts as an intracellular DNA sensor (PRR), recognizing foreign or self-cytosolic DNA and cyclic dinucleotides. Upon ligand binding, DDX41 interacts with STING, activating downstream TBK1 and IRF3, leading to type I interferon production and antiviral/inflammatory responses. DDX41 maintains genome stability by resolving R-loops, preventing accumulation that otherwise leads to DNA replication stress and abnormal hematopoiesis. Germline and somatic mutations of DDX41 are linked to familial predisposition and sporadic development of myeloid malignancies, often acting as a tumor suppressor. DDX41 is a multifunctional protein connecting nucleic acid sensing, genome maintenance, and splicing, with major roles in both immunity and hematopoietic stem cell regulation.

Other names

DDX41DEAD-box helicase 41DEAD box protein 41DEAD (Asp-Glu-Ala-Asp) box polypeptide 41AbstraktABSMGC8828MPLPFDEAD box protein abstrakt homolog

For immune response modulation: - Sensing of double-stranded DNA or cyclic dinucleotides through DEAD domain, leading to STING-TBK1-IRF3-type I interferon activation - Protein interactions influencing RNA splicing and genome stability - Potential tumor suppression via maintenance of genomic integrity and regulation of hematopoiesis