Probable ATP-dependent RNA helicase DDX46 (DDX46)

Probable ATP-dependent RNA helicase DDX46 (DDX46) is an enzyme and member of the DEAD-box protein family, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif[1][7]. It functions as a putative RNA helicase involved in pre-mRNA splicing by facilitating the unwinding of RNA secondary structures and is an essential component of the 17S U2 small nuclear ribonucleoprotein (snRNP) complex in the spliceosome[1][6]. DDX46 plays a key role in post-transcriptional regulation of gene expression, cell proliferation, and development, and has been implicated in modulation of innate immune responses by regulating nuclear export of antiviral transcripts[2]. Abnormal DDX46 expression correlates with tumorigenesis and poor prognosis in several cancers, making it a potential target for anti-cancer therapy[4][9]. However, no direct DDX46-targeting drugs are currently available.

Other names

DEAD box protein 46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46KIAA0801FLJ25329PRPF5 homologPrp5Prp5-like DEAD-box proteinRNA helicase DDX46

Not applicable (no approved or investigational drugs directly targeting DDX46 are currently in development or clinical use; in experimental settings, knockdown or inhibition of DDX46 reduces tumorigenicity and modulates immune signaling)