Probable ATP-dependent RNA helicase DDX49 (DDX49)

Probable ATP-dependent RNA helicase DDX49 (DDX49) is an RNA helicase enzyme of the DEAD-box family, characterized by conserved ATPase and RNA-binding motifs that provide robust ATP-dependent RNA unwinding activity[1][3]. DDX49 is essential for various aspects of RNA metabolism, including the regulation of mRNA export from the nucleus and the control of pre-ribosomal RNA transcription and stability[1][3]. It is localized in both the nucleoplasm and nucleolus within cells and modulates global protein translation by affecting both mRNA export and ribosome biogenesis[1][3]. DDX49 promotes cell proliferation and colony-forming potential; its expression is elevated in various cancers, suggesting a pathogenic role in oncogenic transformation and tumor progression[1][2]. Dysregulation of DDX49 and related DEAD-box helicases is implicated in cancer and potentially other diseases involving aberrant RNA processing or cell cycle control[1][2]. No approved drugs or biomarker applications have been directly associated with DDX49 as of this date[1][3].

Other names

DEAD-box helicase 49DDX49FLJ10432Dbp8DEAD box protein 49R27090_2DEAD (Asp-Glu-Ala-Asp) box polypeptide 49