Probable ATP-dependent RNA helicase DDX53 (DDX53)

Probable ATP-dependent RNA helicase DDX53 (DDX53) is a member of the DEAD-box RNA helicase family, characterized by its ability to unwind RNA in an ATP-dependent manner. It contains several domains common to other DEAD-box proteins, is encoded by an intronless gene on the human X chromosome, and is primarily expressed in cancer cells. DDX53 has been implicated in tumorigenesis through interactions with microRNAs and histone deacetylases, and is associated with stem cell-like properties, autophagy, and resistance to anti-cancer drugs. It may serve as a biomarker for certain cancers (notably breast adenocarcinoma) and has also been linked to Autism Spectrum Disorder. The 3D molecular structure has recently been elucidated, providing a basis for structure-based drug design targeting its helicase domain for cancer therapy.

Other names

DDX53CAGECT26Cancer-associated gene proteinCancer/testis antigen 26DEAD-box helicase 53DEAD-box protein CAGEDEAD (Asp-Glu-Ala-Asp) box polypeptide 53

Inhibition of ATP-dependent RNA helicase activity, interference with RNA metabolic processes central to cell proliferation and survival