Probable ATP-dependent RNA helicase DDX59 (DDX59)

Probable ATP-dependent RNA helicase DDX59 (DDX59) is an enzyme of the DEAD-box helicase family, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif. Like other DEAD-box helicases, DDX59 is predicted to use the energy of ATP hydrolysis to unwind RNA duplexes, thus regulating various aspects of RNA metabolism including RNA processing, splicing, transport, translation, and degradation[2][3][4][7]. DDX59 is found in the cytoplasm and nucleus and is associated with orofaciodigital syndrome V[7]. While specific small-molecule modulators or approved drugs targeting DDX59 are not documented, DEAD-box helicases as a family are considered putative therapeutic targets due to their roles in cancer and other diseases[1][4][6].

Other names

ZNHIT5Zinc finger HIT domain-containing protein 5Zinc finger HIT-type containing 5OFD5DEAD box protein 59DEAD (Asp-Glu-Ala-Asp) box polypeptide 59DKFZP564B1023putative ATP-dependent RNA helicase DDX59