Probable ATP-dependent RNA helicase DExD-box helicase 52 (DDX52)

DDX52 is a member of the DEAD-box family of RNA helicases, characterized by two conserved domains responsible for ATP binding and RNA remodeling activities. It plays a fundamental role in ribosome biogenesis by promoting the processing and maturation of precursor rRNA, particularly the 47S pre-rRNA, leading to protein synthesis and cell growth. DDX52 is rapidly upregulated during wound healing and tissue regeneration in vertebrates and is essential for post-embryonic development and organ growth. Deficiency or suppression of DDX52 results in stunted growth and defective regeneration, while its overexpression can promote growth in early developmental stages. Human DDX52 is associated with several diseases, and the DEAD-box helicase family, in general, is linked to cancer and viral replication, highlighting their potential as therapeutic targets.

Other names

DDX52ROK1HUSSY-19DEAD box protein 52ATP-dependent RNA helicase ROK1-likeHUSSY19DEAD-box helicase 52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52

Not established for direct inhibitors. General mechanism involves inhibition of rRNA synthesis and RNA transcription (as seen with Actinomycin D, which inhibits RNA polymerase I and thus rRNA synthesis)