Probable ATP-dependent RNA helicase DHX37 (DHX37)

Probable ATP-dependent RNA helicase DHX37 (DHX37) is an enzyme belonging to the DEAH-box family of RNA helicases, characterized by conserved ATPase and RNA-binding domains. Its primary function is to facilitate the maturation of the small ribosomal subunit by catalyzing the unwinding of RNA secondary structures and the removal of U3 snoRNP from preribosomal particles during ribosome biogenesis. DHX37 contains a canonical DEAH ATPase/helicase core and a unique carboxy-terminal domain required for interaction with regulatory proteins such as UTP14A. It is expressed broadly, with crucial roles in early testis and brain development, and has been implicated in genetic diseases related to developmental anomalies and certain cancers. Disruption or mutation of DHX37 is associated with syndromes such as 46,XY sex reversal and neurodevelopmental disorders with brain anomalies[1][5][6][2].

Other names

DEAH-box helicase 37DDX37KIAA1517MGC4322Dhr1DEAH box protein 37DEAD/H box polypeptide 37DEAD/DEAH box helicase DDX37NEDBAVCSRXY11MGC2695putative ATP-dependent RNA helicase DHX37

ATP-dependent unwinding of RNA during ribosome assembly and pre-rRNA processing