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Target intelligence / Profile preview
Probable cation-transporting ATPase 13A5 (ATP13A5)
- Target
- ATP13A5
- Molecular classification
- Transporter, Enzyme, P-type ATPase, P5 subfamily transporter
01
Overview
Probable cation-transporting ATPase 13A5 (ATP13A5) is a member of the P5 subfamily of P-type ATPases, a large superfamily of cation and lipid pumps capable of transporting various ions across membranes using ATP hydrolysis[2]. ATP13A5 is implicated in cation (potentially metal ion) transmembrane transport[7], and has been detected in numerous tissues including the central nervous system, bone marrow, adrenal gland, and adipose tissue[3][4]. While there is evidence linking ATP13A5 to cellular proliferation and hypothesized, but not proven, involvement in blood-brain barrier vascular differentiation, its specific physiological and pathological roles remain incompletely characterized[5]. There are currently no approved drugs, established biomarkers, or major disease associations directly tied to ATP13A5 function.
- Other names
- Probable cation-transporting ATPase 13A5ATP13A5FLJ16025UNQ488/PRO1004P5-ATPase isoform 5putative cation-transporting ATPase 13A5ATPase type 13A5P5-ATPase
02
Biological functions
Cation transportATPase activityMetal ion transportMonoatomic cation transmembrane transporter activityCell proliferationPotential role in blood-brain barrier regulation
03
Disease associations
Other (evidence for roles in cell proliferation, but no strong disease linkage is established in literature as of 2024)
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