Probable E3 SUMO-protein ligase RNF212 (RNF212)

Probable E3 SUMO-protein ligase RNF212 (RNF212) is an enzyme required for the regulation of crossing-over during meiosis, where it functions as a SUMO E3 ligase by stabilizing key meiotic recombination factors such as MSH4, MSH5, and TEX11[2][3]. RNF212 localizes to recombination sites, mediates the sumoylation of proteins involved in meiotic chromosome synapsis, and acts as a limiting factor for crossover designation, thus ensuring accurate genetic exchange and diversity[1][2][3]. Polymorphisms in RNF212 are associated with male infertility (Spermatogenic failure 62) and influence naturally occurring variation in recombination rates in humans[2][3]. This protein operates in concert with related factors such as HEI10 and RNF212B, with regulatory roles that are critical for pairing and exchange of genetic material between homologous chromosomes during gamete formation[1][2][3].

Other names

RING finger protein 212Probable E3 SUMO-protein transferase RNF212FLJ38841SPGF62ZHP3RNF212