Probable E3 ubiquitin-protein ligase DTX3 (DTX3)

Probable E3 ubiquitin-protein ligase DTX3 (DTX3) is an enzyme encoded by the DTX3 gene in humans on chromosome 12q13.3[4][1]. DTX3 is a member of the Deltex protein family of RING-type E3 ubiquitin ligases and is primarily localized in the nucleus[1][4]. It catalyzes the transfer of ubiquitin from E2 conjugating enzymes to target proteins, influencing proteasomal degradation, protein stability, and cellular signaling[1]. DTX3 also has specialized roles in catalyzing ADP-ribosylation/ubiquitylation cross-modifications and may ubiquitylate nucleic acids or ADP-ribosylated substrates in vitro[2][3]. Biologically, DTX3 is implicated in cell growth, differentiation, apoptosis, and the DNA damage response. It is generally considered a tumor suppressor in several cancers (such as triple-negative breast cancer and esophageal cancer), but can have tumor-promoting roles depending on the context and isoform expression[1][4]. DTX3 is regarded as a potential diagnostic and therapeutic target in oncology, though therapeutic drugs modulating DTX3 directly are not currently known.

Other names

RNF154Deltex3FLJ34766Protein deltex-3RING finger protein 154RING-type E3 ubiquitin transferase DTX3deltex3deltex 3E3 ubiquitin ligasedeltex homolog 3

Drug mechanisms not established; as an E3 ligase, drugs could act by modulating DTX3’s ubiquitination activity or stabilizing/destabilizing specific protein substrates