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Probable fibrosin-1 (FBRS)

Target: FBRS
Molecular classification: Other (Probable fibrosin-1 is best classified as a cytokine/growth factor-like protein—it is a lymphokine with growth factor activity but is not an enzyme, transporter, classical receptor, transcription factor, or ion channel)

Overview

Probable fibrosin-1 (FBRS) is a protein secreted by activated lymphocytes and classified as a lymphokine, with probable growth factor activity. It is predicted to stimulate proliferation of fibroblasts and contributes to myofibroblast accumulation during wound healing, suggesting a putative role in scarring and fibrotic processes. The gene is protein-coding and associated with several conditions via gene-gene association studies; however, its mechanism and clinical significance are poorly characterized and not yet targeted by approved drugs.

Other names: FBRSFBS1FBSFLJ11618FibrosinProbable fibrosin-1Putative fibrosin-1Fibrogenic lymphokineFibrosin 1Probable fibrosin-1 long transcript protein

Biological functions

Fibroblast proliferation stimulationGrowth factor activityUpregulation of myofibroblast appearance during wound healingInduction of scarring/fibrosis

Disease associations

Fibrosis/scarring (experimental, wound healing context)Autism spectrum disorder (gene association, not mechanistic)Midface hypoplasia, hearing impairment, elliptocytosis, nephrocalcinosis (gene association per OMIM, not well-characterized mechanisms)

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