Probable G-protein coupled receptor 141 (GPR141)

Probable G-protein coupled receptor 141 (GPR141) is an orphan Class A (rhodopsin-like) G protein-coupled receptor encoded by the GPR141 gene in humans[3][4][6]. Highly expressed in myeloid-lineage cells such as neutrophils, monocytes, macrophages, and dendritic cells, GPR141 functions as a negative regulator of immune responses and inflammation, notably by suppressing excessive myeloid cell activation[1]. Recent research indicates GPR141 is a promoter of breast cancer proliferation, migration, and epithelial to mesenchymal transition by modulating p53 and mTOR1 signaling and influencing the tumor microenvironment[2][4]. Although not yet targeted by approved drugs, GPR141 is under investigation as a potential therapeutic target for both cancer and immune-mediated disorders.

Other names

PGR13G-protein coupled receptor PGR13putative G-protein coupled receptor 141probable G-protein coupled receptor 141

No approved drugs; mechanism of action inferred from gene/protein modulation studies—e.g., GPR141 knockdown impedes breast cancer proliferation through p53 restoration and mTOR1 pathway attenuation.