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Target intelligence / Profile preview
Probable G protein-coupled receptor 173 (GPR173)
- Target
- GPR173
- Molecular classification
- G protein-coupled receptor, Receptor, Class A orphan GPCR
01
Overview
Probable G protein-coupled receptor 173 (GPR173) is a highly conserved member of the class A (rhodopsin-like) orphan G protein-coupled receptor family. It is primarily expressed in the brain and reproductive organs, where it serves as the putative receptor for the neuropeptide phoenixin. GPR173 is implicated in the regulation of the hypothalamic-pituitary-gonadal axis, including potentiation of luteinizing hormone secretion and the coordination of reproductive cycles. Additional proposed roles involve modulation of food intake, memory and learning, anxiety, inflammatory response, and cardiac protection, likely mediated through neuropeptide signaling. As of the latest research, GPR173 remains an orphan receptor without marketed therapeutic ligands but represents an emerging target for neuroendocrine and reproductive disorders.
- Other names
- SREB3Super conserved receptor expressed in brain 3G protein-coupled receptor 173
02
Mechanism of action
Modulation of neuroendocrine pathways via ligand (e.g., phoenixin) binding, resulting in altered luteinizing hormone secretion Possible additional modulation of synaptic inhibitory signaling
03
Biological functions
Regulation of hypothalamic-pituitary-gonadal axisReproductive functionModulation of luteinizing hormone secretionRegulation of food intakeModulation of learning and memoryRegulation of anxietyInflammatory responseCardiac protection
04
Disease associations
Reproduction-related disordersNeuroendocrine dysfunctionPotential for neuropsychiatric or metabolic disorders (inferred from GPCR roles broadly)
05
Safety considerations
Not established due to absence of approved drug targeting this receptor
06
Interacting drugs
None with established clinical use or approval as of current sources
2 more in the full profile.
07
Biomarkers
None specifically established for patient selection or efficacy monitoring as of current data; expression level in hypothalamus and ovary is of research interest
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