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Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6)

Target: PPIL6
Molecular classification: Enzyme, Other

Overview

PPIL6 encodes a protein structurally similar to cyclophilin-type peptidyl-prolyl cis-trans isomerases, which in general accelerate protein folding by catalyzing the isomerization of peptide bonds at proline residues. Unlike other PPIases, PPIL6 is believed to be enzymatically inactive, with no detectable peptidyl-prolyl cis-trans isomerase activity. It is predicted, based on bioinformatic data, to have roles in transcriptional regulation, but these functions remain to be experimentally validated. PPIL6 is not currently associated with any disease roles nor targeted by any therapeutic drugs[3][8][2][4].

Other names: Probable inactive peptidyl-prolyl cis-trans isomerase-like 6PPIL6peptidylprolyl isomerase like 6PPIaseCyclophilin-like protein PPIL6Rotamase PPIL6radial spoke 12 homolog (RSPH12)bA425D10.6MGC41939dJ919F19.1probable inactive peptidyl-prolyl cis-trans isomerase-like 6putative inactive peptidyl-prolyl cis-trans isomerase-like 6

Biological functions

Protein foldingIsomerization of proline imidic peptide bondsRegulation of transcription by RNA polymerase II

Disease associations

Other

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