Probable maltase-glucoamylase 2 (MGAM2)

MGAM2 is a mammalian protein and paralog to maltase-glucoamylase (MGAM). It belongs to the glycoside hydrolase family 31 but, in placental mammals (including humans), key catalytic residues are mutated, so traditional alpha-glucosidase activity is absent. Instead, MGAM2 contains a large, extracellular threonine-rich evolutionarily hypervariable (EHV) domain. Genomic data show MGAM2 is selectively expressed in basal-like breast cancer, correlating with immune signatures and better patient survival, suggesting a potential biomarker role. Its loss of enzymatic function and structural divergence from MGAM highlight its probable immunological role and lack of current therapeutic targeting[1][2].

Other names

Probable maltase-glucoamylase 2GlucoamylaseMGAM2Maltase-glucoamylase (alpha-glucosidase) pseudogeneGlucan 1,4-alpha-glucosidasePutative maltase-glucoamylase 2Putative maltase-glucoamylase-like protein FLJ16351

None established; no known drug mechanisms targeting MGAM2