Probable RNA polymerase II nuclear localization protein SLC7A6OS (SLC7A6OS)

Probable RNA polymerase II nuclear localization protein SLC7A6OS (SLC7A6OS) is a conserved protein in vertebrates implicated in the nuclear import of RNA polymerase II. SLC7A6OS is named for its antisense transcription relative to the SLC7A6 amino acid transporter gene but is not itself a transporter. In model organisms, SLC7A6OS, and its homologs such as yeast Iwr1, direct the nuclear import of fully assembled RNA polymerase II by binding the enzyme in the cytoplasm and facilitating its transport into the nucleus. Once in the nucleus, SLC7A6OS is released and can be recycled. Knockdown of SLC7A6OS orthologs in zebrafish leads to marked developmental defects in the central nervous system, indicating a key developmental role[1]. In humans, genetic variants in SLC7A6OS have been implicated in progressive myoclonic epilepsy (EPM12)[3]. The protein has sites for phosphorylation and is predicted to localize both to the nucleus and cytoplasm. Despite its name, SLC7A6OS does not belong to transporter or receptor molecular classes, but regulates nucleocytoplasmic trafficking of transcriptional machinery[2][3][5][6]. Key points: - SLC7A6OS is **not a transporter** or canonical receptor/enzyme; it acts as a shuttling factor for RNA polymerase II[1][5][6]. - It is **not currently considered a drug target**, with no known interacting drugs or clinically actionable mechanism of action[3]. - It is associated with **developmental functions** and rare neurodevelopmental diseases such as progressive myoclonic epilepsy[3]. - Its **main function** is in the regulation of RNA polymerase II nuclear import, crucial for gene expression and proper development[1][3][6].

Other names

SLC7A6OSSolute carrier family 7 member 6 opposite strandFLJ13291Iwr1Solute carrier family 7 member 6 opposite strand transcriptEPM12ADAMS proteinase-related proteinprotein SLC7A6OS