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Target intelligence / Profile preview
Probable rRNA-processing protein EBP2 (EBNA1BP2)
- Target
- EBNA1BP2
- Molecular classification
- Other
01
Overview
Probable rRNA-processing protein EBP2 (EBNA1BP2) is a conserved nucleolar protein required for the processing of 27S pre-rRNA and the biogenesis of the ribosomal large subunit, enabling RNA binding activity[4][5]. It localizes predominantly to the nucleolus and functions as a scaffold protein in rRNA processing and ribosome assembly[2][3]. EBNA1BP2 also interacts directly with Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1), mediating the tethering and faithful partitioning of EBV episomes during cell division, a function essential for latent EBV genome maintenance in host cells[1][2]. While it plays dual roles in normal ribosome biogenesis and viral episome segregation, EBNA1BP2 is not a classical therapeutic target such as a receptor or enzyme and currently has no known drug interactions or biomarker/safety concern associations[2][4][5].
- Other names
- EBP2NOBPEBNA1-binding protein 2Nucleolar protein p40nuclear FGF3 binding proteinputative rRNA-processing protein EBP2P40
02
Biological functions
rRNA processingRibosomal large subunit biogenesisRNA bindingViral episome segregationNucleolar scaffold protein
03
Disease associations
Viral infection (specifically in the context of Epstein–Barr virus latency and genome maintenance)Other (potential roles in cell proliferation via ribosome biogenesis)
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