Probable serine carboxypeptidase CPVL (CPVL)

The Probable serine carboxypeptidase CPVL is an enzyme encoded by the CPVL gene, predominantly expressed in human monocytes and macrophages, with high mRNA levels in the heart and kidney[1][3][4][5]. Structurally, CPVL possesses features typical of serine carboxypeptidases, although its enzymatic activity has not yet been confirmed experimentally[1][3]. It is localized to the endoplasmic reticulum and endosomal/lysosomal compartments, and is found in lamellipodia and membrane ruffles of macrophages associated with the secretory pathway and actin cytoskeleton remodeling[3]. CPVL is hypothesized to function in the processing of antigens for MHC class I and II presentation, in peptide trimming within lysosomes, and possibly in regulating cytokine and chemokine secretion, though precise biological roles remain to be clarified[1][3][4][5]. Genetic deletion is linked to Wilms tumor, and variants are associated with diabetic nephropathy susceptibility; it is also down-regulated in response to inflammation and may serve as a biomarker for infectious disease severity[1][3][5]. No approved pharmaceuticals are known to directly modulate CPVL function currently.

Other names

Carboxypeptidase vitellogenic-likeVLPPSEC0124UNQ197/PRO223VCP-like proteinhVLPCarboxypeptidase, vitellogenic-likeVitellogenic carboxypeptidase-like proteinCarboxypeptidase WUGCP-Mac carboxypeptidaseHVLPPutative serine carboxypeptidase CPVL