Probable UDP-sugar transporter protein SLC35A4 (SLC35A4)

SLC35A4 is a member of the solute carrier family 35 of nucleotide sugar transporters, localized to intracellular organelles such as the Golgi and the mitochondrial inner membrane[1][4][5]. It is predicted to function as a transporter, facilitating the import of CDP-ribitol across organellar membranes, and is notably required for maintaining cellular respiration and for the regulation of protein translation in response to stress[1][4][5]. It does not transport CMP-sialic acid, UDP-galactose, or UDP-N-acetylglucosamine[5][6]. Gene mutations have been implicated in severe neurodevelopmental disorders known as developmental and epileptic encephalopathies[1]. SLC35A4 belongs to a large family of nucleotide sugar transporters, which are essential for glycoprotein and glycolipid biosynthesis[2]. There are no currently known drugs targeting this transporter, and its implication in disease is primarily through loss-of-function mutations.

Other names

Solute carrier family 35 member A4SLC35A4 microproteinSLC35A4-MPSLC35A4 upstream open reading frame proteinSolute carrier family 35 (UDP-galactose transporter), member A4Solute carrier family 35, member A4Tumor rejection antigen

Not established for therapeutic agents; protein mediates cellular uptake of CDP-ribitol into intracellular compartments