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Target intelligence / Profile preview
Procaspase-3
- Molecular classification
- Enzyme, Cysteine-aspartic acid protease, Zymogen
01
Overview
Procaspase-3 is the inactive zymogen form of caspase-3, a cysteine-aspartic acid protease that plays a central role in the execution phase of apoptosis (programmed cell death). Upon activation by initiator caspases, procaspase-3 is cleaved at specific aspartic residues, resulting in the formation of active caspase-3. Active caspase-3 then catalyzes the hydrolysis of hundreds of cellular substrates to execute apoptosis rapidly. Procaspase-3 levels are often elevated in tumor tissues.
02
Mechanism of action
Direct activation of procaspase-3
03
Biological functions
ApoptosisProteolysisCell death
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the broad substrate specificity of activated caspase-3Dysregulation can contribute to both cancer progression and resistance to therapies
06
Interacting drugs
PAC-1
07
Biomarkers
Procaspase-3 levels in tumor tissues
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