Target intelligence / Profile preview

Procathepsin L

Molecular classification: Enzyme, Protease, Cysteine protease, Lysosomal protein

Overview

Procathepsin L is the inactive zymogen form of cathepsin L, a lysosomal cysteine protease. It is involved in intracellular protein catabolism, antigen processing, and tumor invasion/metastasis. Recent research highlights its role in inflammation, particularly in sepsis, where it interacts with TLR4 and RAGE to promote inflammatory signaling. Neutralizing antibodies against procathepsin L show therapeutic potential.

Mechanism of action

Inhibition of procathepsin L binding to TLR4/RAGE, preventing downstream inflammatory signaling.

Biological functions

Protein degradationAntigen processingRegulation of cell growthInflammatory signaling

Disease associations

CancerInflammationSepsis

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