Target intelligence / Profile preview

Procoagulant phosphatidylserine-exposing platelet membrane

Molecular classification: Other, Receptor

Overview

Other names: Procoagulant plateletsCOAT plateletsBalloon plateletsSuperactivated plateletsPlatelet factor 3PF3Phosphatidylserine-positive plateletsPS-exposing platelet membrane

Mechanism of action

Phosphatidylserine blockade and inhibition of coagulation factor complex assembly (tenase and prothrombinase) on the platelet surface, leading to reduced thrombin generation.

Biological functions

Blood coagulationHemostasisApoptosisOther

Disease associations

Cardiovascular diseaseInflammationOther

Interacting drugs

Annexin A5

5 more in the full profile.

Biomarkers

Annexin V bindingProcoagulant microvesiclesThrombin generation assay}

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