Production of isocladosporin

"Production of isocladosporin" refers to the fungal biosynthetic pathway responsible for generating the secondary metabolite isocladosporin, a process primarily documented in the fungus Cladosporium cladosporioides [2, 3]. It is characterized as a biological process or metabolic pathway rather than a discrete therapeutic target molecule, such as a receptor or enzyme. This biosynthetic route involves a coordinated gene cluster encoding specialized enzymes, specifically highly reducing and non-reducing iterative type I polyketide synthases (PKS), such as Cla2 and Cla3 [2, 3]. Isocladosporin itself is a diastereomer of cladosporin, a natural product recognized for its potent antimalarial properties through the selective inhibition of Plasmodium falciparum cytosolic lysyl-tRNA synthetase (PfKRS) [1, 6, 9]. While isocladosporin has been investigated for its own biological activities, including herbicidal and antibacterial effects, the production pathway itself is a subject of study for metabolic engineering and chemical ecology rather than a direct target for drug intervention [3, 7].

Other names

Isocladosporin biosynthesisIsocladosporin biosynthetic pathwayIsocladosporin metabolic process

Not applicable