Proenkephalin-B (PDYN)

Proenkephalin-B (PDYN) is a neuropeptide precursor protein that undergoes proteolytic processing to yield dynorphins and neoendorphins, endogenous opioid peptides that primarily activate the κ-opioid receptor. Dynorphin peptides, including dynorphin A, dynorphin B, and neoendorphins, play key roles in modulating nociception, emotion, reward, stress response, and motor control. PDYN expression is prominent in the basal ganglia, hippocampus, cortex, and spinal cord. Defects in PDYN have been implicated in neurodegenerative diseases such as Spinocerebellar Ataxia 23 and implicated in various neuropsychiatric and pain disorders. Alternative splicing and nuclear localization of certain PDYN isoforms suggest possible noncanonical, non-opioid roles in transcriptional regulation in neurons. Drugs that modulate the dynorphin/κ-opioid system are of interest for the treatment of pain, addiction, and mood disorders

Other names

Proenkephalin-BProdynorphinAlpha-neoendorphinBeta-neoendorphinBig dynorphinDynorphin A(1-17)Dynorphin A(1-13)Dynorphin A(1-8)Dynorphin ADynorphin BDynorphin B(1-13)Dynorphin B-29Leu-enkephalinLeumorphinRimorphinBig DynPENKBSCA23Preprodynorphinpreproenkephalin Bneoendorphin-dynorphin-enkephalin prepropeptide

Agonism or antagonism of κ-opioid receptor via endogenous dynorphins or drug ligands. Regulation of opioid peptide signaling, which affects neuronal excitability and neurotransmitter release.