Target intelligence / Profile preview

Progerin

Molecular classification: Structural Protein, Nuclear Protein, Mutant Protein

Overview

Progerin is a mutant, truncated form of the nuclear structural protein lamin A, arising from a specific mutation in the LMNA gene. It is most notably implicated in Hutchinson–Gilford progeria syndrome (HGPS), a rare genetic disorder characterized by features of accelerated aging. Progerin also accumulates at lower levels during normal physiological aging and influences nuclear structure, DNA repair, chromatin organization, cellular senescence, and oxidative stress.

Mechanism of action

Farnesyltransferase inhibition

Biological functions

Nuclear StructureDNA Repair (Impaired)Chromatin Organization (Altered)Cellular Senescence (Promotion)Oxidative Stress (Increased)

Disease associations

Hutchinson–Gilford Progeria Syndrome (HGPS)AgingCancer (Context Dependent)

Safety considerations

Potential off-target effects of drugs targeting progerinComplex interactions with other cellular pathwaysTissue-specific effects need consideration

Interacting drugs

Lonafarnib

Biomarkers

Plasma progerin levels

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