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Target intelligence / Profile preview
Progesterone Receptor A (PR-A)
- Target
- PR-A
- Molecular classification
- Nuclear hormone receptor, Receptor, Transcription factor
01
Overview
Progesterone receptor A (PR-A) is one of the two major isoforms of the progesterone receptor (PR), a nuclear hormone receptor that mediates the effects of progesterone. PR-A lacks the first 164 amino acids found in PR-B and can function as both a transcriptional activator and repressor, often antagonizing the effects of PR-B. It plays a crucial role in regulating reproductive tissue development and function, and is implicated in various diseases, including breast cancer and menstrual cycle disorders.
- Other names
- PGR isoform ANuclear receptor subfamily 3 group C member 3
02
Mechanism of action
Ligand binding induces receptor dimerization, translocation to the nucleus, binding to progesterone response elements (PREs) on DNA, and recruitment of co-regulators to modulate gene transcription. PR-A can act as both a transcriptional activator and repressor, and can antagonize PR-B function.
03
Biological functions
Transcriptional regulationReproductive tissue developmentModulation of progesterone signaling
04
Disease associations
Breast cancerMenstrual cycle disordersPreterm labor/deliveryOther solid tumors/cancers
05
Safety considerations
Increased risk of thromboembolic events with some progestinsPotential for off-target effects due to interaction with other steroid receptors
06
Interacting drugs
Progesterone
1 more in the full profile.
07
Biomarkers
PR-A expression levels in breast cancer tissueRatio of PR-A to PR-B expression
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