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Target intelligence / Profile preview
Progesterone Receptor B (PR-B)
- Target
- PR-B
- Molecular classification
- Nuclear hormone receptor, Transcription factor, Steroid hormone receptor
01
Overview
Progesterone receptor B (PR-B) is a full-length nuclear hormone receptor acting primarily as an activator for progesterone-mediated gene expression. It differs structurally from its shorter counterpart PRA due to an extra N-terminal region conferring unique regulatory properties. Its activity underlies many normal reproductive processes—and imbalances between its expression relative to other isoforms contribute significantly to pathologies such as certain cancers.
- Other names
- PRBPGR-BProgesterone Receptor isoform B
02
Mechanism of action
Ligand binding, receptor dimerization, nuclear translocation, DNA binding (to progesterone response elements), co-regulator recruitment, transcriptional activation/repression.
03
Biological functions
Transcriptional regulationRegulation of reproductive processesCell proliferationCell differentiationDevelopment
04
Disease associations
Breast cancerEndometrial cancerReproductive disorders
05
Safety considerations
Increased risk of thromboembolic events with some progestinsPotential for off-target effects with synthetic progestinsDevelopment of resistance to anti-hormonal therapies
06
Interacting drugs
Progesterone
3 more in the full profile.
07
Biomarkers
PR-B expression levels in breast cancer tissuePR-B/PR-A ratio in endometrial tissue
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