Progestin and adipoQ receptor family member 3 (PAQR3)

Progestin and adipoQ receptor family member 3 (PAQR3), also known as Raf kinase trapping to Golgi (RKTG), is a seven-transmembrane protein anchored in the Golgi apparatus, belonging to the PAQR receptor family[1][2][6]. PAQR3 modulates cellular signaling by sequestering Raf-1 kinase to the Golgi, suppressing the Raf/MEK/ERK pathway to regulate cell proliferation, migration, and tumor progression[2][3][7]. It acts as a scaffold for cholesterol biosynthesis by anchoring Scap/SREBP complexes, mediates energy metabolism, influences insulin sensitivity, and plays key roles in inflammation and fibrosis, especially in metabolic disease and diabetic complications[1][4][6]. PAQR3 is recognized as a tumor suppressor gene, downregulated in various cancers, and is being investigated for its potential as a therapeutic target and biomarker in oncology and metabolic disorders[2][4][6].

Other names

PAQR3RKTG (Raf kinase trapping to Golgi)Progestin and adipoQ receptor family member IIIRaf kinase trapping to Golgi

Inhibition of Raf/MEK/ERK pathway (by sequestration of Raf kinases at the Golgi); Downregulation of SREBP-mediated cholesterol synthesis (by interfering with Scap/SREBP anchoring); Modulation of PI3K and AKT-related pathways (regulation of insulin sensitivity and metabolism).