Programmable DNA nanostructure for drug delivery (null)

Programmable DNA nanostructures are synthetic, self-assembled nucleic acid architectures designed to encapsulate and deliver drug molecules to specific cells or tissues. By leveraging the sequence programmability of DNA, these nanocarriers can be engineered to form precise three-dimensional shapes (e.g., tetrahedrons, cages, hydrogels) that allow tailored cargo loading and release. Modifications with targeting ligands, stimuli-responsive elements (responsive to pH, GSH, mechanical force, etc.), or other functional groups further enable controlled, site-specific, and efficient drug release, while minimizing off-target effects and toxicity. This platform is actively explored for applications in cancer therapy, gene delivery, and other precision medicine strategies, but is not itself a molecular target, receptor, or enzyme.

Other names

programmable DNA scaffoldDNA nanostructure drug deliveryDNA-based nanocarrierDNA hydrogel drug deliveryDNA mechanocapsuleDNA nanocage

Physical encapsulation of drug within DNA nanostructure followed by programmed/stimuli-responsive release at the target site (e.g., in response to pH, GSH, ATP, force) Targeted delivery via functionalization with ligands for cell-specific uptake Overcoming cellular efflux and drug resistance by direct delivery inside cells