Programmed Cell Death Protein 1 Delta 42 Isoform (Δ42PD1)

Programmed cell death protein 1 delta 42 isoform (Δ42PD1) is an alternatively spliced variant of PD-1. Unlike canonical PD-1, Δ42PD1 does not bind to PD-L1 or PD-L2 and instead promotes inflammation through the induction of pro-inflammatory cytokines. It is expressed in activated T cells, B cells, NKT cells, and monocytes, and is upregulated in pathological conditions. It does not deliver classical inhibitory signals. It has potential applications in modulating immune responses during infection or vaccination strategies.

Other names

PD1 Delta 42PDCD1 Delta 42sΔ42PD1soluble extracellular Δ42PD1

Induction of pro-inflammatory cytokine release (IL-β, IL-6, TNF)