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Target intelligence / Profile preview
Programmed cell death protein 1 receptor (PD-1)
- Target
- PD-1
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane protein, Receptor
01
Overview
PD-1 is a cell surface receptor that acts as an immune checkpoint, downregulating immune responses by inhibiting antigen receptor signaling in T lymphocytes when engaged by its ligands PD-L1 and PD-L2. This mechanism prevents autoimmunity but can be exploited by cancerous or infected tissues to evade immune surveillance. Blocking the PD-1/PD-L1 interaction is a key strategy in cancer immunotherapy.
- Other names
- CD279PDCD1
02
Mechanism of action
Checkpoint inhibitors targeting PD-1 block the interaction between PD-1 and its ligands (PD-L1/PD-L2), thereby preventing the inhibitory signal and reactivating cytotoxic lymphocyte activity against tumor targets.
03
Biological functions
Immune checkpoint inhibitionRegulation of T cell activationPromotion of self-toleranceRegulation of immune responseApoptosis modulation
04
Disease associations
CancerAutoimmunityInfection
05
Safety considerations
Immune-related adverse events (irAEs)Increased autoimmunity risk
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
PD-L1 expression in tumorsPD-1 expression on tumor-infiltrating lymphocytes
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