Programmed cell death protein 7 (PDCD7)

Programmed cell death protein 7 is a 59 kDa nuclear protein encoded by the PDCD7 gene. It is associated with the U11 small nuclear ribonucleoprotein (snRNP), a component of the minor U12-type spliceosome that is responsible for the splicing of U12-type introns in pre-mRNA. PDCD7 promotes apoptosis when overexpressed and plays a role in specific apoptotic processes in T-cells, and is also implicated in RNA splicing. Studies in mouse T-cells indicate involvement in apoptotic pathways related to glucocorticoids, staurosporine, and ceramide-mediated signaling. It is not considered a druggable therapeutic target (e.g., receptor, enzyme, transporter, or transcription factor), but rather as a component of the splicing machinery. It is not currently established as a therapeutic target and primarily functions as a component of the minor spliceosome in eukaryotic cells. There is limited evidence implicating PDCD7 directly as a disease-driving gene or direct therapeutic target in common disease categories; it is not a drug target nor is it known to interact with approved drugs. No known biomarkers for patient selection or monitoring, no interacting drugs, and no documented safety concerns as a direct therapeutic target.

Other names

hES18HES18ES1859KU11/U12 snRNP 59Kapoptosis-related protein ES18