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Programmed Death-Ligand 1 Messenger RNA (PD-L1 mRNA)

Target: PD-L1 mRNA
Molecular classification: mRNA

Overview

Programmed death-ligand 1 messenger RNA (PD-L1 mRNA) is the transcript that encodes the PD-L1 protein. Its expression is regulated by inflammatory cytokines, particularly interferon-gamma (IFN-γ). Overexpression of PD-L1 mRNA in tumors leads to immune evasion, making it a relevant target for cancer immunotherapy. Therapeutic strategies involve modulating PD-L1 mRNA levels to enhance anti-tumor immune responses.

Other names: CD274 mRNA

Mechanism of action

N/A

Biological functions

Template for PD-L1 protein translationRegulation of PD-L1 protein expression

Disease associations

CancerImmune evasion

Biomarkers

PD-L1 mRNA expression levels in tumors

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