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Target intelligence / Profile preview
Progranulin (PGRN)
- Target
- PGRN
- Molecular classification
- Growth factor, Glycoprotein
01
Overview
Progranulin is an evolutionarily conserved secreted glycoprotein essential for normal development, tissue repair/regeneration, neuronal health/protection, immune modulation/inflammation control, with dysregulation contributing directly to major human diseases including frontotemporal dementia/ceroid lipofuscinosis when deficient—and cancer when overexpressed.
- Other names
- Granulin-epithelin precursorGEPProepithelinPC cell-derived growth factorPCDGFAcrogranin
02
Mechanism of action
Modulates signaling pathways such as MAPK/ERK and PI3K/AKT/GSK3β cascades; interacts with TNFRs, Ephrin-type A receptor 2, Perlecan, and Sortilin.
03
Biological functions
Cell growth and survivalWound repairTissue regenerationNeuroprotectionLysosomal functionImmune modulationAngiogenesis
04
Disease associations
Frontotemporal lobar degenerationNeuronal ceroid lipofuscinosisCancerAlzheimer’s disease
05
Safety considerations
Overexpression linked to aggressive tumor growth and metastasis.Deficiency leads to neurodegenerative diseases.
06
Biomarkers
Progranulin levels in FTLD diagnosisProgranulin expression in cancer prognosis
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