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Progranulin Degradation Pathway
- Molecular classification
- Pathway, Protein degradation pathway
01
Overview
The Progranulin degradation pathway is crucial for regulating cellular levels and biological activity of progranulin, a glycoprotein involved in neuroprotection, inflammation regulation, and lysosomal function. The pathway involves lysosomal degradation mediated by sortilin and cathepsin L, extracellular cleavage by proteases, and alternative trafficking routes involving prosaposin. Dysregulation of this pathway is implicated in neurodegenerative diseases.
02
Biological functions
Regulation of protein levelsLysosomal function regulationNeuroprotection regulationInflammation regulation
03
Disease associations
Neurodegenerative diseaseFrontotemporal lobar degeneration (FTLD)Neuronal ceroid lipofuscinosisAlzheimer’s disease
04
Safety considerations
Dysregulation can lead to neurodegeneration
05
Biomarkers
Progranulin levels
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