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Target intelligence / Profile preview
Prohibitin (PHB)
- Target
- PHB
- Molecular classification
- Chaperone, Adaptor protein, Scaffold protein, RNA regulator
01
Overview
Prohibitin (PHB) refers to a highly conserved family of proteins found in eukaryotes. In humans, it is encoded by the PHB gene located on chromosome 17q21. There are two main types: Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2), which form a large heteromeric complex primarily in the inner mitochondrial membrane but are also present in the nucleus and plasma membrane. Prohibitins play multifaceted roles across several cellular processes including energy metabolism, cell proliferation, apoptosis, senescence, signal transduction, and transcriptional control. Mutations or altered expression of prohibitin have been linked with various diseases including cancer and neurodegenerative diseases.
- Other names
- PHB1PHB2Prohibitin-1Prohibitin-2
02
Mechanism of action
Modulation of mitochondrial function, signal transduction pathways, and gene expression; apoptosis regulation
03
Biological functions
Energy metabolismCell proliferationApoptosisSenescenceSignal transductionTranscriptional controlMitochondrial biogenesisOXPHOS regulationMitochondrial dynamics regulation
04
Disease associations
CancerNeurodegenerative diseaseIschemic injury
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