Target intelligence / Profile preview

Prohibitin 1 (PHB1)

Target: PHB1
Molecular classification: Chaperone protein, Scaffold protein, Mitochondrial protein

Overview

Prohibitin 1 (PHB1) is a highly conserved protein primarily localized to the inner mitochondrial membrane, but also found in the nucleus, cytosol, and plasma membrane. It functions as a chaperone or scaffold for respiratory chain proteins, maintaining optimal mitochondrial morphology and function, and regulating reactive oxygen species (ROS) production. PHB1 is also involved in angiogenesis, transcriptional modulation, and cell signaling. It has been identified as a receptor for certain viruses and interacts with numerous other proteins to regulate diverse cellular events.

Biological functions

Mitochondrial integrity and biogenesisRegulation of reactive oxygen species (ROS)AngiogenesisTranscription modulationSignal transductionCellular aging

Disease associations

CancerViral infectionCardiovascular diseaseAging-related diseases

Safety considerations

Potential for off-target effects due to pleiotropic rolesModulation of ROS levels may have complex consequences

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