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Target intelligence / Profile preview
Prohibitin 2 (PHB2)
- Target
- PHB2
- Molecular classification
- Chaperone protein, Mitochondrial protein, Transcription factor, Receptor coregulator
01
Overview
Prohibitin 2 (PHB2) is a highly conserved protein that plays crucial roles in various cellular functions, including mitochondrial maintenance, cell cycle regulation, and apoptosis. It forms complexes with Prohibitin 1 (PHB1) in the mitochondrial inner membrane and functions as a mitophagy receptor. PHB2 is implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders, making it a potential therapeutic target.
- Other names
- BAPREAD-prohibitinBAP37
02
Biological functions
Mitochondrial assembly and functionRegulation of cell cycle progressionCell proliferation and differentiationApoptosis regulationMitophagy receptorTranscriptional regulationSignal transductionInflammation regulationMetabolism regulation
03
Disease associations
CancerNeurodegenerative diseaseMetabolic disorderAging-related processesCardiac diseaseKidney disease
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