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Target intelligence / Profile preview
Proinflammatory Cytokine Secretion (TNF-alpha-induced IL-8) (TNFα-induced IL-8 Secretion)
- Target
- TNFα-induced IL-8 Secretion
- Molecular classification
- Cytokine signaling pathway, Inflammatory pathway
01
Overview
Proinflammatory cytokine secretion, specifically the TNF-α-induced production and secretion of IL-8, is a key inflammatory pathway. TNF-α stimulates cells, leading to NF-kB and PI3K/Akt activation, resulting in increased IL-8 expression. IL-8, a chemokine, recruits neutrophils and other immune cells, amplifying inflammation. This process is implicated in various diseases, including autoimmune disorders and cytokine storms. Therapeutic strategies target TNF-α or downstream signaling molecules to reduce IL-8 production and its inflammatory effects.
- Other names
- TNF-alpha induced IL-8 productionIL-8 secretion induced by TNF-αCXCL8 secretion induced by TNF-alpha
02
Mechanism of action
Inhibition of TNF-α signaling to reduce IL-8 production; blockade of IL-8 receptor (CXCR1/CXCR2) to prevent neutrophil recruitment
03
Biological functions
Immune responseInflammationNeutrophil chemotaxisSignal transduction
04
Disease associations
Autoimmune disordersChronic inflammatory diseasesSepsisARDS (Acute Respiratory Distress Syndrome)Cytokine stormCancer (tumor microenvironment)
05
Safety considerations
Increased risk of infection with TNF-α inhibitorsPotential for immunosuppressionRisk of exacerbating certain infectionsOff-target effects of broad-spectrum NF-kB/PI3K inhibitors
06
Interacting drugs
TNF-α inhibitors (e.g., Infliximab, Etanercept, Adalimumab)
3 more in the full profile.
07
Biomarkers
Serum TNF-α levelsSerum IL-8 levelsNeutrophil count in affected tissueNF-kB activation status in cells
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