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50S Ribosomal Subunit (Domain V) (50S (Domain V))

Target: 50S (Domain V)
Molecular classification: Ribosomal Subunit, RNA, Non-coding RNA

Overview

The 50S ribosomal subunit is the larger component of the prokaryotic 70S ribosome. Domain V of the 23S rRNA within the 50S subunit houses the peptidyl transferase center (PTC), which catalyzes peptide bond formation during protein synthesis. It is a primary target for many antibiotics, which inhibit protein synthesis by binding to sites on or near domain V. The subunit consists of 23S rRNA, 5S rRNA, and over 30 distinct proteins (r-proteins).

Other names: Prokaryotic Large Ribosomal Subunit23S rRNA Domain VPeptidyl Transferase Center (PTC)

Mechanism of action

Inhibition of protein synthesis by blocking peptide bond formation or exit tunnel function.

Biological functions

Protein SynthesisPeptide Bond FormationTranslation

Disease associations

Infection

Safety considerations

Antibiotic resistanceOff-target effects of antibiotics

Interacting drugs

Macrolides

3 more in the full profile.

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