Prokineticin receptor 2 (PROKR2)

Prokineticin receptor 2 (PROKR2) is a G protein-coupled receptor encoded by the PROKR2 gene and is structurally related to other prokineticin receptors. It is expressed primarily in the brain (notably the suprachiasmatic nucleus and olfactory bulb) and the testes, where it binds the prokineticin family ligands, mainly PROK2. Upon ligand binding, PROKR2 signals through Gq-mediated phospholipase C activation and subsequent Ca²⁺ release, as well as MAPK and cAMP signaling cascades. These pathways regulate critical physiological processes, including the migration of GnRH neurons, development of the olfactory bulb, coordination of circadian rhythms, angiogenesis, and smooth muscle contraction. Pathogenic variants in PROKR2 are associated with Kallmann syndrome and other reproductive and neurodevelopmental disorders[1][2][4][5]. PROKR2 is considered a potential therapeutic target, but no approved drugs specifically target this receptor at present.

Other names

PKR2PK-R2GPR73L1GPR73bGPRg2dJ680N4.3G-protein coupled receptor 73-like 1G-protein coupled receptor I5EHH3KAL3

Ligand (prokineticin) binding activates Gq protein signaling, leading to phospholipase C activation, inositol triphosphate (IP3) production, and intracellular calcium release[1][2]. Activation of MAPK and cAMP signaling pathways[2].