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Target intelligence / Profile preview
Prolactin Receptor (PRLR)
- Target
- PRLR
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
The prolactin receptor (PRLR) is a type I cytokine receptor that mediates the effects of prolactin, growth hormone, and placental lactogen. It is essential for mammary gland development and lactation, and also plays roles in metabolism, immune response, and reproduction. Aberrant PRLR signaling is implicated in various cancers, particularly breast cancer, where it promotes cell proliferation, migration, and invasion. PRLR is being explored as a therapeutic target, with antibody-drug conjugates showing promise in treating PRLR-positive breast cancers.
02
Mechanism of action
Targeting PRLR signaling to inhibit cell proliferation, migration, and invasion in cancer cells.
03
Biological functions
Signal transductionMammary gland developmentLactationAdipose tissue function regulationPancreatic islet cell proliferation/differentiationImmune response modulationCell proliferationCell survival
04
Disease associations
Cancer (Breast, Prostate, Cervical, Ovarian, Pancreatic)Polycystic Ovarian Syndrome (PCOS)
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